Until Heisenberg's breakthrough -- which soon came to be called matrix mechanics, because it manipulated matrices, or lattices, of numbers, with weird but satisfying results -- there was no real connection between Niels Bohr's semiclassical picture of quantum physics and the ground.
Two years later, Heisenberg came up with his now-famous (and widely co-opted by philosophers and playwrights) uncertainty principle, which in essence says you can't simultaneously pin down the location and momentum of a subatomic particle. It is one of the pillars of the so-called Copenhagen interpretation of quantum theory, which upended classical Newtonian physics and revealed matter and energy as fundamentally discontinuous and unpredictable.
With the declassification of important wartime documents, it is now clear from private statements made by Werner Heisenberg, German's leading theorist, that Heisenberg and his colleagues made several key mistakes in calculating what would be needed for a bomb, contributing to pessimism and poor progress in their fission research. In particular, Heisenberg's calculation of the critical mass--the amount of uranium necessary to sustain a nuclear chain reaction--was based on a faulty premise and flawed by arithmetical mistakes.
Other works online: A scientist's case for the classics by Werner Heisenberg, Harper's, May 1958
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